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Nettle Root and Estradiol
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isocelessmith
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Join date: Jul 2010
Posts: 10

Nettle Root suppresses SHBG, so we can expect to raise both Testosterone and Estradiol. I have read that SHBG binds more strongly to Testosterone than to Estradiol, or binds preferentially to Testosterone, so it stands to reason that Stinging Nettle Root would favorably alter the Testosterone: Estradiol ratio.


However, in my own experience, symptomatically, this is not the case. When I take 300mg Nettle Root extract 1-2 times a day, the elevation of testosterone is unmistakable, but the elevation of estradiol is more prominent, even to the point of persistent nipple soreness.

It is it possible that under certain circumstances, Nettle Root's might do more harm than good to T:E levels?

Before anyone asks, I am on TRT. I am not yet on an AI (I'm working on that).

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PureChance
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Join date: Oct 2009
Posts: 1547

everyone seems to respond differently to herbal supplements. they work for some, but not others, and can have weird uncontrollable effects at times.

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KSman
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Join date: Aug 2006
Posts: 7975

It will then also reduce E2-SHBG binding, increasing free E2.

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Hardasnails
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Join date: Nov 2002
Posts: 760

it also has anti aromatase property, but more so by lowering shbg your bio T goes up and so does your bio e2 as ksman pointed out.

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gdevine
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Join date: Jan 2011
Posts: 38

Nettle Root I believe suppresses the conversion to DHT which has negative outcomes as well. I stopped taking it after reading KSman's discussion on it in previous posts.

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Hardasnails
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Join date: Nov 2002
Posts: 760

gdevine wrote:
Nettle Root I believe suppresses the conversion to DHT which has negative outcomes as well. I stopped taking it after reading KSman's discussion on it in previous posts.


That is why you get levels montiored.
nettle is great for BPH. I take 1,000 mgs a day.

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KSman
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Join date: Aug 2006
Posts: 7975

HAN, I think that you are taking some DHT type meds? Those are prostate friendly?

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Hardasnails
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Join date: Nov 2002
Posts: 760

taking proviron at 25 mgs to help with shbg due to thyroid increasing it. At 25 mgs a day it will not aggravate prostate over 50 mgs it can. I love proviron as it acts slightly as anti E but ups my Bio T. My strength has been getting insane even on 25 mgs a day. My hair has never been fuller, shinier, and silkier then ever, a pee fine. I will check DHT on next labs. I take nettles to complement the proviron in keeping shbg in check as well as prostate healthy. On nettles I have full ejaculations more then normal.

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KSman
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Join date: Aug 2006
Posts: 7975

Are DHT lab tests sensitive to proviron to some degree?

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Hardasnails
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Join date: Nov 2002
Posts: 760

we will find out my freind but the nettle may be counteracting it. So it will be a good way to find could a low dose of proviron and nettle actually be a viable method for dealing with SHBG issues. Like I said I am always the human guinea pig LOL

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oscar31280
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Join date: Nov 2009
Posts: 160

Hardasnails wrote:
taking proviron at 25 mgs to help with shbg due to thyroid increasing it. At 25 mgs a day it will not aggravate prostate over 50 mgs it can. I love proviron as it acts slightly as anti E but ups my Bio T. My strength has been getting insane even on 25 mgs a day. My hair has never been fuller, shinier, and silkier then ever, a pee fine. I will check DHT on next labs. I take nettles to complement the proviron in keeping shbg in check as well as prostate healthy. On nettles I have full ejaculations more then normal.


how much does that dose lower your estrogen. This maybe useful to others that are extremely sensitive to AI's like myself. Also if its a mild anti-e why is this not suggested to your patients that are having trouble with AI's being way to strong and causing sides? If its mild enough it could be the solution to me staying on TRT and not coming off do to no way to control estrogen.

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isocelessmith
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Join date: Jul 2010
Posts: 10

Gentlemen,

Thanks for your replies. I appreciate the info.

As far as my own little n = 1 experiment goes, I have gone off Nettle Root altogether and have seen the estrogenic sides go away. Nipple sensitivity is gone and sluggishness and moodiness are much improved.

Regards,

IS

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