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Lab Work, Blood Testing and Symptoms
 

VTBalla34
Level 5

Join date: Mar 2009
Posts: 7536

tuscans wrote:
Regarding blood testing, how many weeks do you recommend using a test, ai and hcg protocol before doing a follow up?
thanks


4-6 weeks is about right. Closer to the higher end of that spectrum for most accurate.

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VTBalla34
Level 5

Join date: Mar 2009
Posts: 7536

Quest 4021x Estradiol (E2) Test

Just a heads up...my Quest district has changed the reference range of their 4021x Estradiol test from 13-54 pg/mL to 0-39 pg/mL.

http://www.questdiagnostics.co...

This may or may not be a nation wide thing and we are the first to adopt it. I can't find any info on it other than that.

I like the new ranges though! Hopefully will make it a little easier for men on TRT to sort out their E2 issues since they will be "above range" much more easily now.

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MDAutry
Level 1

Join date: Feb 2009
Posts: 11

I am attempting to find out "why I'm cold all of the time?" I haven't seen this explained, if someone can point me in the right direction I would greatly appreciate the help...

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VTBalla34
Level 5

Join date: Mar 2009
Posts: 7536

MDAutry wrote:
I am attempting to find out "why I'm cold all of the time?" I haven't seen this explained, if someone can point me in the right direction I would greatly appreciate the help...


This is indicative of low thyroid function (hypothyroid). Your body's metabolism is slowed to the point that your body temperature drops. This is especially applicable to the extremities.

Body temperature is a very good indicator of thyroid function.

Though ironically, some people with low thyroid function can also feel HOT a lot of the time--sweating when other people are cold, etc. But their body temperatures are still on the lower side. Still haven't figured that one out.

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PureChance
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Join date: Oct 2009
Posts: 1547

sweating can be caused by an electrolyte imbalance potentially caused by low Aldosterone (tied to progesterone/cortisol production). Thyroid/Cortisol issues are linked so it is not any stretch to include Aldosterone in the mix of systems effected.

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MDAutry
Level 1

Join date: Feb 2009
Posts: 11

Thank you both for the replies...

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CJD8791
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Join date: Apr 2010
Posts: 29

Should the folate test from LabCorp be Folate (folic acid) or Folate (RBC and Serum)?

Also, would there be any benefit to getting labs to check for inflammation? i.e. CRP, homocysteine, etc? If so what would you recommend?

Thank you.

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Jrm2465
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Join date: Apr 2012
Posts: 12

Can you explain the causes of brittle hair, ridges in the nails, and thinned skin on the top of the hands? Is TRT a treatment that will reverse this? Thanks

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KSman
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Join date: Aug 2006
Posts: 7815

TRT can fix thinning skin which is collagen loss from a catabolic state. My skin was thin and when pinched up it was slow to recover. TRT fixed that in a few months. Brittle hair can also be a symptom of hypothyroidism. Read the advice for new guys sticky.

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Jrm2465
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Join date: Apr 2012
Posts: 12

Thanks KSman for all the time you have invested to help others.

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Tunapancake
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Join date: Jan 2011
Posts: 249

I would like to add that if you have thyroid issues. DEMAND a thyroid ultrasound, tyroglobulin, antibodies test along with a full thyroid panel with free t4 free t3. It can literally save your life. Many people have goiter, nodules, and cysts, which can be revealed by ultrasound. Avoid soy products they can cause thyroid issues.

Also if your pinky finger does not pass the third line on your ring finger and you have dry elbows you are predisposed to thyroid issues and should keep a close eye on it. If you have this in both hands you inherit it from both sides of the family. I learned all this from a thyroid specialist who has been working since 1948 his name is Boris Catz btw he is 86 and still sees patients in Los Angeles.

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KSman
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Please stick to the point of this sticky.

Please only ask about things that are general to the topic that have not been made clear already.

Do not discuss your personal situation here. Read the beginning of the first post in this sticky.

Use your own thread for things that pertain to you.

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Master_P
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Join date: Aug 2012
Posts: 78

KSman - Can you please confirm if the first post in this sticky contains a typo? It reads as follows:

Labs to never do and timing issues:
-DO NOT test E2 ultra sensitive


... my question is why not? Many of the other posts indicate that we need to measure E2. The levels will be lower in men, so isn't an ultra sensitive test preferable?

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KSman
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There were many debates long ago. Do not know all of the issues that were current. With Labcorp, the standard test works great. And some labs used to not report in the ranges that we are interested in. Really needs to be in the context of each specific lab. You may have pulled your finding out of context.

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MassiveNate
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Join date: Oct 2012
Posts: 42

I am confused by your comment about hugging puppies and babies.
I'm new to TRT (one month) and I have a puppy AND a baby - and I hug them as much as I can.
Would you please explain what you meant?
Thanks,
Nate

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KSman
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Join date: Aug 2006
Posts: 7815

Orgasm, babies, puppies and other huggy and bonding events involve a release of prolactin which could affect your prolactin lab work. Note that prolactin release at orgasm is one of the primary reasons that men have a period of time after orgasm where sexual activity cannot happen. There is some study data somewhere that shows that holding a baby increases a man's prolactin.

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Burqueno
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Join date: Jul 2012
Posts: 4

The quest diagnostics sensitive (4021x) is not available, what test should I use Estradiol or Estradiol Ultra sensitive? My guess is they combined the sensitive with one and not sure how to tell which one.

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Kingsix
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Join date: Mar 2013
Posts: 40

sorry- moved to own thread.

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HouKN98
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Posts: 141

Kingsix, you'll need to start your own thread so we can track your case in one thread. I'm a newbie, too, and I noticed the guys here don't like it when you post about your own situation in the stickies or start different threads about your own situation. Also, read up on the stickies.

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iw84aces
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Join date: Mar 2013
Posts: 883

if someone is on weekly injections yes i read the protocol :). when would you suggest lab work be taken? end of week?

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KSman
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Join date: Aug 2006
Posts: 7815

I suggest 1/2 between injections as that number will be more representative of your overall T levels.

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TRTman
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Join date: Jan 2012
Posts: 6

I have been getting the Ultrasensitive test (range <29) 30289 for E2 and just saw that KSman stated "For TRT, use the basic LabCorp serum E2 test or Quest Sensitive 4021x. DO NOT USE Quest ULTRASENTIVE! There are some similar issues with other testing labs as well.". When I look up 4021x http://www.questdiagnostics.co... it states that the range is <39.

I realize others have posted on this, but could not find a definitive answer if this new version is a solid test. I am meeting with my doctor in the morning. Does anyone know if this is a reliable E2 test from Quest? If not, which is the best test? I am with Kaiser and they send to San Juan Capistrano Quest, which doesn't do 4021.

Any thoughts or suggestions are appreciated.

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TRTman
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Join date: Jan 2012
Posts: 6

I just found this 2013 study, called "Evaluating the Accuracy of Direct Estradiol Immunoassays for Human Male Serum" http://edrv.endojournals.org/...stracts/SUN-524

I read through it and don't have the experience to understand it. If anyone has education in this area, could you check it out and let me know if this sheds any light on what we should be looking for in an estradiol test?

Here is another interesting and exciting article http://www.aacc.org/...Estradiol.aspx#

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KSman
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I have not kept up-to-date on the different offerings from Quest. One problem is when the labs have a high cut off value and when they report <29, what do you do with that. And some cut off around 17, so you have no idea how low you are and then cannot calculate an AI dose adjustment.

http://www.questdiagnostics.co...

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TRTman
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Posts: 6

Thank KSman.

I find when doing the E2 test with the range of <29, that I get a number response. My last test came back 8. The <29 is just the reference range. There is another test I have done that isn't as sensitive that has a range of <50 and just comes back with <50 if my number is, in fact, less than 50. If it is above 50, I get the actual number.

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