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Headhunter
Level 4

Join date: Oct 2002
Location: Ohio, USA
Posts: 15058

The future of TRT, I hope?

Role of SARMs in Androgen Therapy for Men

http://jcem.endojournals.org/...full/84/10/3459

Currently used androgenic formulations for replacement therapy are largely restricted to injectable or skin delivery formulations of testosterone or testosterone esters. Marketed injectable forms of testosterone esters (such as testosterone enanthate, propionate, or cypionate) produce undesirable fluctuations in testosterone blood levels, with supraphysiological concentrations early, and subnormal levels towards the end of the period before the next injection, providing an unsatisfactory profile and in some cases undesired side effects. Skin patches do provide a better blood level profile of testosterone, but skin irritation and daily application still limit the usefulness and acceptability of this form of therapy (1, 20, 21, 22). Oral preparations such as fluoxymesterone and 17-methyltestosterone are not currently used due to concerns about liver toxicity linked to the 17-alkyl group and because of somewhat lower efficacy. Thus, these compounds are considered obsolete (1, 20) and do not represent a viable form of therapy.

The discovery and development of SARMs provides the opportunity to design molecules that are not only orally active, but that target AR in different tissues to elicit the desired activity for each of the key indications benefiting from androgen therapy.

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Headhunter
Level 4

Join date: Oct 2002
Location: Ohio, USA
Posts: 15058

Latest research:

http://endo.endojournals.org/...bstract/148/1/4

A novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator (BMS-564929) has been identified, and this compound has been advanced to clinical trials for the treatment of age-related functional decline. BMS-564929 is a subnanomolar AR agonist in vitro, is highly selective for the AR vs. other steroid hormone receptors, and exhibits no significant interactions with SHBG or aromatase. Dose response studies in castrated male rats show that BMS-564929 is substantially more potent than testosterone (T) in stimulating the growth of the levator ani muscle, and unlike T, highly selective for muscle vs. prostate.

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Dr.PowerClean
Level 1

Join date: Sep 2007
Location:
Posts: 1127

SARMS appear to be the future of HRT. They seem to have such a positive safety profile and benign nature that they would throw the T haters into their own version of "roid rage." Doc

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plymouth city
Level 1

Join date: Mar 2007
Location:
Posts: 73

Good stuff hunter, thanks for the link

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playmaker08
Level 1

Join date: Jul 2005
Location: Michigan, USA
Posts: 576

Wow, who knew that MHP's SARM product would be the future in TRT!(sarcasm)

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plymouth city
Level 1

Join date: Mar 2007
Location:
Posts: 73

playmaker08 wrote:
Wow, who knew that MHP's SARM product would be the future in TRT!(sarcasm)


why the sarcasm? Criticisms of SARM/opinions of yours would be appreciated.

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playmaker08
Level 1

Join date: Jul 2005
Location: Michigan, USA
Posts: 576

Because MHP created a product called SARM-X, which the ingredients consist of:

200mg Diandrone, Trans-4-Hydroxy-3-Methoxycinnamic Acid

Diandrone is actually a fancy name for DHEA. While Trans-4-Hydroxy-3-Methoxycinnamic Acid is Ferulic Acid which can act as an anti-inflammatory (it is found in whole wheat, brown rice, etc).

SARMs are real, SARM-X by MHP is real crap. It is going to be a little while before real SARMs are available, and you will have to go through your doctor to attain them.

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plymouth city
Level 1

Join date: Mar 2007
Location:
Posts: 73

playmaker08 wrote:
Because MHP created a product called SARM-X, which the ingredients consist of:

200mg Diandrone, Trans-4-Hydroxy-3-Methoxycinnamic Acid

Diandrone is actually a fancy name for DHEA. While Trans-4-Hydroxy-3-Methoxycinnamic Acid is Ferulic Acid which can act as an anti-inflammatory (it is found in whole wheat, brown rice, etc).

SARMs are real, SARM-X by MHP is real crap. It is going to be a little while before real SARMs are available, and you will have to go through your doctor to attain them.


Thanks for the heads up.

Check your PM

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KSman
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Join date: Aug 2006
Location:
Posts: 7476

playmaker08 wrote:
Because MHP created a product called SARM-X, which the ingredients consist of:

200mg Diandrone, Trans-4-Hydroxy-3-Methoxycinnamic Acid

Diandrone is actually a fancy name for DHEA. While Trans-4-Hydroxy-3-Methoxycinnamic Acid is Ferulic Acid which can act as an anti-inflammatory (it is found in whole wheat, brown rice, etc).

SARMs are real, SARM-X by MHP is real crap. It is going to be a little while before real SARMs are available, and you will have to go through your doctor to attain them.


We may be getting access to these via research chems way before they become FDA approved. Can these be detected in urine?

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KSman
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Join date: Aug 2006
Location:
Posts: 7476

No sooner said than done!

Article about such things in sports:

http://www.technologyreview.co...

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Dopa
Level 1

Join date: Apr 2006
Location: Ontario, CAN
Posts: 367

No thank you on the SARMs.

Replace what is missing. Can't get any better than that.

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