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Are You Inflamed?
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T NATION
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Are You Inflamed?
by Mike Roussell
04/19/10

Inflammation helps protect the body... and then it kills you. Mike Russell shows you how to smash it before it smashes your goals.

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honest_lifter
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Oh please, would you stop mentioning supplements in your articles?! I have no desire to find out about superior supplements and/or better ways to take care of my health!

*sarcasm*

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BulletproofTiger
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"Let's Compare COXs" LOL

Seriously though, thanks for comparing COXs, err, I mean thanks for the info :)

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Tex Ag
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Good timing. Quick question, should we avoid aspirin or just try to minimize taking it? Or, just let our stomachs be our guide?

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bearwolfden
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Tex Ag wrote: should we avoid aspirin or just try to minimize taking it? Or, just let our stomachs be our guide?

Following Tex... Aspirin is supposed to be good for heart health...
Is there no dose that is beneficial for the heart, not bad for the stomach lining and does not negatively affect COX-1 production?

from the American Heart Association:
Aspirin

Goal: Low-dose aspirin in people at higher risk of coronary heart disease (especially those with a 10-year CHD risk of 10 percent or greater).

Recommendations
Do not recommend for patients with aspirin intolerance (or allergy).
Low-dose aspirin increases risk for gastrointestinal bleeding and hemorrhagic stroke. Do not use in people at increased risk for these diseases.
Benefits of reducing cardiovascular risk outweigh these risks in most patients with higher coronary risk.
Doses of 75 to 160 milligrams per day are as effective as higher doses. Consider 75 to 160 milligrams aspirin per day for people at higher risk (especially those with a 10-year CHD risk of 10 percent or greater).

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mcguffin83
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Wouldn't users of curcumin fall victim to the same problems associated with the use of pharmaceutical COX-2 inhibitors such as Vioxx? Is curcumin less effective at blocking COX-2?

COX-2 is found in the vascular endothelium and is involved in the production of PGI2 from arachidonic acid (PGI2 functions to inhibit platelet activation). It is thought that by blocking this function COX-2 inhibitors increase the risk of stroke and/or heart attack.

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oinky222
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great article. a couple questions i have are:

1) is there any risk of inhibiting the COX-2 enzyme too much? would you recommend only consuming curcumin on days that we are feeling particularly sore or beat down, or would it be a good supplement to consume daily?

2) is there any specific time of day thats better to consume curcumin? like would consuming it immediately post-workout be a bad idea?

Thanks for the help.

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Ben.K
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for anyone who cannot afford any supplements like FA3, fish oil, or curcumin, what is the best way to deal with inflammation?
In other words, what kind of diet? We all know already (or should) about sleep, tissue work, contrast showers, etc.

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BulletproofTiger
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My recommendation for you Ben.K would be

1) Lots of veggies, low sugar, low vegetable oils (and of course low trans fats)
2) Fish Oil - low dose Flameout
3) bulk curcumin powder online (although Curcumin 500 is really not that expensive, and you could also do a low dose, and still probably get a decent benefit)
3) FA3 - bulk coconut oil (several threads about it), bulk EVOO (costco/sams club/grocery store/online), and bulk evening primrose oil (online)
4) consider going gluten and dairy free for a while

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Fulldeplex
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Nice article, but I would have liked to see more info about the human clinical trials Mike mentioned. Now I still have some questions.

Mike Said:
"I know that sounds almost like blasphemy, but the compounds in your system that move the inflammatory process along (i.e. inflammatory mediators) cause vasodilatation and increased blood flow to the damaged areas รข?? your muscles. There's even some research to show that exercise has an anti-inflammatory effect."

If the inflammatory process is so important to muscle growth doesn't this mean that muscle growth can be decreased by taking in too much curcumin?
Are there any human trails that could answer this question?

Some research (maybe not the best quality) shows that curcumin decreases muscle damage after a workout. see: http://www.jissn.com/.../1/14/abstract/

I wonder if this is a good or a bad thing...

Oh jeah, I would also have like to see some No-BS research results about what causes inflammation. Some mention that sugar is proflammatory and so it high blood sugar/glucose caused by ingestion of carbs. Omega 6's, stress and so on would also cause inflammation.

How much of this is backed up by science as in human clinical trails?

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alfredoe
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Hi All. The article fails to identify the number one cause of CHRONIC INFLAMMATION: carbohydrates(omega 6). Every time you ingest any type of carbohydrate, simple or complex,you release insulin. The more insulin you have in your system the more inflammation you create.

So try to get a diet low in carbohydrates by eating only vegetables and few fruits,protein of all kinds and "good" fats, take 3.000 mg of fish oil per day and a turmeric supplement.

read more at omega-3-fish-oil-wonders.com/anti-inflammation-diet.html

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oinky222
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alfredoe wrote:
Hi All. The article fails to identify the number one cause of CHRONIC INFLAMMATION: carbohydrates(omega 6). Every time you ingest any type of carbohydrate, simple or complex,you release insulin. The more insulin you have in your system the more inflammation you create.

So try to get a diet low in carbohydrates by eating only vegetables and few fruits,protein of all kinds and "good" fats, take 3.000 mg of fish oil per day and a turmeric supplement.

read more at omega-3-fish-oil-wonders.com/anti-inflammation-diet.html



that's not true at all. insulin can increase arachadonic acid, but the contribution of insulin to inflammation is nothing compared to an overabundance of omega-6's in the diet, too little omega-3's, or a high percentage of visceral body fat. if you knew anything about nutrition you would know that there is no difference between simple and complex carbs, as there are many low-glycemic simple carbs and many high-glycemic complex carbs, so the distinction is pointless. and most fruits tend to have a low-glycemic load, so the consumption of all the vitamins, minerals, antioxidants, and other phytonutrients in fruit is well worth the small consumption of a little sugar.

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HK24719
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oinky222 wrote:
alfredoe wrote:
Hi All. The article fails to identify the number one cause of CHRONIC INFLAMMATION: carbohydrates(omega 6). Every time you ingest any type of carbohydrate, simple or complex,you release insulin. The more insulin you have in your system the more inflammation you create.

So try to get a diet low in carbohydrates by eating only vegetables and few fruits,protein of all kinds and "good" fats, take 3.000 mg of fish oil per day and a turmeric supplement.

read more at omega-3-fish-oil-wonders.com/anti-inflammation-diet.html



that's not true at all. insulin can increase arachadonic acid, but the contribution of insulin to inflammation is nothing compared to an overabundance of omega-6's in the diet, too little omega-3's, or a high percentage of visceral body fat. if you knew anything about nutrition you would know that there is no difference between simple and complex carbs, as there are many low-glycemic simple carbs and many high-glycemic complex carbs, so the distinction is pointless. and most fruits tend to have a low-glycemic load, so the consumption of all the vitamins, minerals, antioxidants, and other phytonutrients in fruit is well worth the small consumption of a little sugar.


Good post, oinky222.

I considered responding to alfredoe's post, but wasn't sure where to even start as his comment was so far off base.

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chrisd2147
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bearwolfden wrote:
Tex Ag wrote: should we avoid aspirin or just try to minimize taking it? Or, just let our stomachs be our guide?


Following Tex... Aspirin is supposed to be good for heart health...
Is there no dose that is beneficial for the heart, not bad for the stomach lining and does not negatively affect COX-1 production?

from the American Heart Association:
Aspirin

Goal: Low-dose aspirin in people at higher risk of coronary heart disease (especially those with a 10-year CHD risk of 10 percent or greater).



The heart healthy benefits of aspirin are based on its ability to knock out COX-1, as the prostaglandins produced normally through that enzyme are responsible for normal platelet aggregation. So if we take out COX-1 naturally the body's ability to clump platelets together will be diminished. COX-2 on the other hand is responsible for the opposite in the blood, meaning that inhibiting COX-2 (like via Vioxx) you would run a risk of forming blood clots unnecessarily (thus increasing the risk of embolytic stroke/heart attack and death).

The AHA and FDA figure that instructing people to take something like a baby aspirin can give them enough of the anti-clotting abilities while minimizing the risks like ulcers.

Is that wise? Well if someone I know was having a stroke or heart attack you better believe I'm giving them an aspirin if possible. But every day? Yeah I'll just stick to eating real foods.

Recommendations
Do not recommend for patients with aspirin intolerance (or allergy).
Low-dose aspirin increases risk for gastrointestinal bleeding and hemorrhagic stroke. Do not use in people at increased risk for these diseases.
Benefits of reducing cardiovascular risk outweigh these risks in most patients with higher coronary risk.
Doses of 75 to 160 milligrams per day are as effective as higher doses. Consider 75 to 160 milligrams aspirin per day for people at higher risk (especially those with a 10-year CHD risk of 10 percent or greater).

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Fulldeplex
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oinky222 wrote:
alfredoe wrote:
Hi All. The article fails to identify the number one cause of CHRONIC INFLAMMATION: carbohydrates(omega 6). Every time you ingest any type of carbohydrate, simple or complex,you release insulin. The more insulin you have in your system the more inflammation you create.

So try to get a diet low in carbohydrates by eating only vegetables and few fruits,protein of all kinds and "good" fats, take 3.000 mg of fish oil per day and a turmeric supplement.

read more at omega-3-fish-oil-wonders.com/anti-inflammation-diet.html



that's not true at all. insulin can increase arachadonic acid, but the contribution of insulin to inflammation is nothing compared to an overabundance of omega-6's in the diet, too little omega-3's, or a high percentage of visceral body fat. if you knew anything about nutrition you would know that there is no difference between simple and complex carbs, as there are many low-glycemic simple carbs and many high-glycemic complex carbs, so the distinction is pointless. and most fruits tend to have a low-glycemic load, so the consumption of all the vitamins, minerals, antioxidants, and other phytonutrients in fruit is well worth the small consumption of a little sugar.


I repeat: How much of this is backed up by science as in human clinical trails?

I did not see any research at all and you guys are talking about what is true or not? Are you kidding me? At least alfredoe had the common decency to post the source of his statements. (although I did not see any research on that site either)



Because I haven't seen any human clinical trails to indicate that Omega 6's are inflammatory. See the article on T-Nation by mike Roussell:
http://www.tmuscle.com/...really_that_bad
And a study by AHA:
http://circ.ahajournals.org/...ourcetype=HWCIT

Carbs might be inflammatory too, but I still need to see the research.
Insulin appears to be very harmful to the body according to some research, but I am not sure if it is directly inflammatory...again: some research would help.
http://www.jacn.org/...bstract/5/5/417
Gary Taubes shows some studies indicating insulin is damaging in 'Good calories, bad calories. I can't show them because I lend the book to someone.


Also, Fructose (from HFCS not fruit) might be more inflammatory than first thought.
(it is very one sighted, but still an interesting watch)


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mwilliamson421
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Blocking COX without Killing Yourself

aka Blue Ball?

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