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Elevated Liver Enzymes
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ANIMAL M0THER
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Join date: Jan 2010
Posts: 534

I had a routine blood lab and my alanine transaminase (ALT) came back at 78 u/l. My doc said he's not too worried about it but wants me to get my lab redone to be safe.

Any idea what caused this? I hardly ever consume alcohol. thanks.

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BONEZ217
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Join date: Feb 2007
Posts: 11473

lifting weights.

google it

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Swolegasm
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Join date: Dec 2010
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Nothing to worry about as far as I know.

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plateau
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What other blood tests did you have?

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ANIMAL M0THER
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Join date: Jan 2010
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plateau wrote:
What other blood tests did you have?


Just the normal...lipid panel, liver function, etc.

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plateau
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Join date: Mar 2006
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ANIMAL M0THER wrote:
plateau wrote:
What other blood tests did you have?


Just the normal...lipid panel, liver function, etc.


Well I know from experience an over-active thyroid will lead to elevated liver stress. Am sure there are plenty of other things that could do.
I did have similar liver score issues while at university, doctor kept trying to tell me I was taking creatine that was the issue (I wasn't), simply muscle damage from weights and sports.

HTH

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ryanbCXG
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Join date: Dec 2010
Posts: 5639

How high have you guys seen liver enzymes elevated from lifting? Especially anyone that lifts at least 6 days a week? I am just asking becuase i know my liver enzymes were fairly elevated but at the time i was doing an asinine amount of volume everyday of the week

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ANIMAL M0THER
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During the time of the test i was doing over 100 pushups and 100 situps everyday and running 2-3 times per week on top of my normal training(3 days a week.) The daily puhsups and situps were to get ready for a PT test, but I hadn't trained for about 5 days prior to the bloodwork.

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cally
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Join date: Jul 2003
Posts: 759

I went through this same issue. I tried to explain to my physician it was likely due to weight lifting. he wouldnt believe me so sent me to a number of specialists who too wouldnt listen.

I had about 20 blood tests, ultrasounds, a bone marrow aspiration (hurt like fuck becuase the little doc couldnt get through my breastplate), and was about to have a liver biopsy when I ended it. 7 years later I still have them elevated but show no symptoms of illness or disease, so in the end it was the weightlifting.

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bam7196
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Join date: Jan 2010
Posts: 65

Cally: they did a bone marrow biopsy on your sternum??? Damn dude, those basically havent been done with any regularity in like 15 years. I have no idea why they did not go iliac crest for you. Much much less dangerous for obvious reasons.

OP: Elevated transaminases (AST/ALT) can occur from many varied processes. Normal for either is ~40. At your level of elevation I would have simply repeated it too. Without clinical correlation it really is something to follow/trend and not a finding at which to start throwing a bunch of subsequent testing.

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cally
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bam7196 wrote:
Cally: they did a bone marrow biopsy on your sternum??? Damn dude, those basically havent been done with any regularity in like 15 years. I have no idea why they did not go iliac crest for you. Much much less dangerous for obvious reasons.

OP: Elevated transaminases (AST/ALT) can occur from many varied processes. Normal for either is ~40. At your level of elevation I would have simply repeated it too. Without clinical correlation it really is something to follow/trend and not a finding at which to start throwing a bunch of subsequent testing.


Ya right in the sternum. I just put my trust in the docs, I mean they were oncologists so I figured they knew what to do. Ha guess not. Wish I had of known this info at that time. Man that hurt.

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twistacannon15
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Join date: Aug 2008
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ryanbCXG wrote:
How high have you guys seen liver enzymes elevated from lifting? Especially anyone that lifts at least 6 days a week? I am just asking becuase i know my liver enzymes were fairly elevated but at the time i was doing an asinine amount of volume everyday of the week


My liver enzymes have come back around 100. If i take a few days off before the blood work though they are in the normal range.

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Damici
Level 10

Join date: Oct 2002
Posts: 3463

BONEZ217 wrote:
lifting weights.

google it


This article talks about that: http://www.ncbi.nlm.nih.gov/...les/PMC2291230/

Question, though: Do the elevated AST, ALT, etc. readings that weight lifting causes mean that it's actually doing some harm to the liver, i.e. is it something we should worry about, or is it just some temporary rise in those values which doesn't signal any actual harm or disease?

In other words, are elevated AST/ALT readings caused by weightlifting necessarily a problem?

Thanks in advance.

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BONEZ217
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Join date: Feb 2007
Posts: 11473

Damici wrote:
BONEZ217 wrote:
lifting weights.

google it


This article talks about that: http://www.ncbi.nlm.nih.gov/...les/PMC2291230/

Question, though: Do the elevated AST, ALT, etc. readings that weight lifting causes mean that it's actually doing some harm to the liver, i.e. is it something we should worry about, or is it just some temporary rise in those values which doesn't signal any actual harm or disease?

In other words, are elevated AST/ALT readings caused by weightlifting necessarily a problem?

Thanks in advance.



I dont know. I have too much other shit to worry about besides whether lifting weights is outpacing my liver's ability to regenerate.

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ANIMAL M0THER
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Join date: Jan 2010
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my second lab came back at 92 u/l. My doc is sending me for an ultra sound.

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kakno
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Join date: Dec 2008
Posts: 2764

Damici wrote:
BONEZ217 wrote:
lifting weights.

google it


This article talks about that: http://www.ncbi.nlm.nih.gov/...les/PMC2291230/

Question, though: Do the elevated AST, ALT, etc. readings that weight lifting causes mean that it's actually doing some harm to the liver, i.e. is it something we should worry about, or is it just some temporary rise in those values which doesn't signal any actual harm or disease?

In other words, are elevated AST/ALT readings caused by weightlifting necessarily a problem?

Thanks in advance.

ALT is short for ALanine Transaminase
AST is short for ASpartate Transaminase
They are enzymes that can transfer amino groups between amino acids. They exist both in the liver and in skeletal muscle since they have an important job in both tissues.

When you train hard, your muscles break, causing these enzymes to leak out into the blood. When your blood is tested, noone sees where it came from, they just se high ALT.

Your liver is (probably) fine, high AST/ALT just means your muscles are temporarily damaged. In this case.

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Damici
Level 10

Join date: Oct 2002
Posts: 3463

kakno wrote:
Damici wrote:
BONEZ217 wrote:
lifting weights.

google it


This article talks about that: http://www.ncbi.nlm.nih.gov/...les/PMC2291230/

Question, though: Do the elevated AST, ALT, etc. readings that weight lifting causes mean that it's actually doing some harm to the liver, i.e. is it something we should worry about, or is it just some temporary rise in those values which doesn't signal any actual harm or disease?

In other words, are elevated AST/ALT readings caused by weightlifting necessarily a problem?

Thanks in advance.

ALT is short for ALanine Transaminase
AST is short for ASpartate Transaminase
They are enzymes that can transfer amino groups between amino acids. They exist both in the liver and in skeletal muscle since they have an important job in both tissues.

When you train hard, your muscles break, causing these enzymes to leak out into the blood. When your blood is tested, noone sees where it came from, they just se high ALT.

Your liver is (probably) fine, high AST/ALT just means your muscles are temporarily damaged. In this case.


Ahh, I see. Nice. I appreciate the explanation.

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Med Pro
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Join date: Sep 2006
Posts: 69

kakno wrote: When you train hard, your muscles break, causing these enzymes to leak out into the blood. When your blood is tested, noone sees where it came from, they just se high ALT

This is correct!

Animal Mother you should halt your workout 2 weeks before your liver panel blood work.

I see a thousands of patients ultrasounds with elevated liver enzymes with normal liver evaluation. Be careful not to be a victim of unnecessary procedures.

READ UP and master the knowledge of what is going on with your health. You may educate a doc or two.

Good Luck!

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ANIMAL M0THER
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Join date: Jan 2010
Posts: 534

I think my problem was caused by the protein powder I was taking. It's the only supp I was taking.

I had right upper quadrant discomfort for a week or so and it has subsided considerably since I stopped taking it.

Any idea how long it takes for the liver to go back to normal?

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cally
Level 5

Join date: Jul 2003
Posts: 759

It was not the result of the protein supplement. The answer was given to you in this thread but you are choosing not to accept it. The answer in right above your post.

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BONEZ217
Level 2

Join date: Feb 2007
Posts: 11473

ANIMAL M0THER wrote:
I think my problem was caused by the protein powder I was taking. It's the only supp I was taking.

I had right upper quadrant discomfort for a week or so and it has subsided considerably since I stopped taking it.

Any idea how long it takes for the liver to go back to normal?



Protein powder is not a supplement. It's food.

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ANIMAL M0THER
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Join date: Jan 2010
Posts: 534

My ALT is now up to 208 u/l. I had abdominal ultrasound last month that came back normal. My hepatitis screen came back normal last year and the year before that. I am going to see a gastroenterologist tomorrow. Any guesses as to what's wrong with me?

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ANIMAL M0THER
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Join date: Jan 2010
Posts: 534

My ALT is now up to 208 u/l. I had abdominal ultrasound last month that came back normal. My hepatitis screen came back normal last year and the year before that. I am going to see a gastroenterologist tomorrow. My symptoms are mild RUQ discomfort, decreased appetite and occassional nausea. Any guesses as to what's wrong with me?

Any guesses as to what's wrong with me?

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Med Pro
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Join date: Sep 2006
Posts: 69

I see a lot of patients as an ultrasound tech with RUQ pain and normal gallbladder/liver ultrasound. What I see a lot of in large intestine dilation (gassiness) without abdomen distention or flatulence. Large intestine gas can press against the gallbladder that could impinge on normal outflow of gallbladder bile. It can mimic symptoms similar to gallbladder stone obstruction. A dilated large intestine can also press against the stomach causing acid reflux and the lungs. Any abnormal bowel movements? If there is no evidence for gallstones, a HIDA scan with CCK stimulation may be considered to evaluate gallbladder function. If the gallbladder ejection fraction is low, then removal of the gallbladder may help. Ultrasound also rules out any signs of liver disease.

If your really worried, use of an extract of milk thistle, but I wouldnt worry.
Just have youre doctor keep an eye on it once or twice a year.

It is well known and documented that ALT levels increase in response to strenuous physical exercise.

Levels of ALT exceeding 2,000 U per L are indicative of liver damage.
Elevations less than 250 U per L are common.

Things that cause ALT elevations:
Acetaminophen
Niacin
aspirin
acetaminophen
ibuprofen
Chaparral leaf
Ephedra
Gentian
Germander
Jin bu huan
Kava
Scutellaria (skullcap)
Senna
Shark cartilage
Vitamin A

Good Luck!

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ANIMAL M0THER
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Join date: Jan 2010
Posts: 534

Med Pro wrote:
I see a lot of patients as an ultrasound tech with RUQ pain and normal gallbladder/liver ultrasound. What I see a lot of in large intestine dilation (gassiness) without abdomen distention or flatulence. Large intestine gas can press against the gallbladder that could impinge on normal outflow of gallbladder bile. It can mimic symptoms similar to gallbladder stone obstruction. A dilated large intestine can also press against the stomach causing acid reflux and the lungs. Any abnormal bowel movements? If there is no evidence for gallstones, a HIDA scan with CCK stimulation may be considered to evaluate gallbladder function. If the gallbladder ejection fraction is low, then removal of the gallbladder may help. Ultrasound also rules out any signs of liver disease.

If your really worried, use of an extract of milk thistle, but I wouldnt worry.
Just have youre doctor keep an eye on it once or twice a year.

It is well known and documented that ALT levels increase in response to strenuous physical exercise.

Levels of ALT exceeding 2,000 U per L are indicative of liver damage.
Elevations less than 250 U per L are common.

Things that cause ALT elevations:
Acetaminophen
Niacin
aspirin
acetaminophen
ibuprofen
Chaparral leaf
Ephedra
Gentian
Germander
Jin bu huan
Kava
Scutellaria (skullcap)
Senna
Shark cartilage
Vitamin A

Good Luck!


Thanks for the response. My ALT is up to 208 now and I have been off any supps and alcohol for over a month. I saw a gastroenterologist yesterday and he ruled out cancer and gallbladder issues. I hade lab work done this morning that included a hep panel and also checking copper, iron, ferritin, and smooth muscle anti body amongst other things. My primary doc told me that he doesn't think I have hep C. I really don't know how I could have contracted hep.

Thanks again.

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